Author

Shivani Saxena

University of Wisconsin SystemORCID 0009-0002-0012-1673Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Amr A. AbdeeniD· 2 shared Bikash Ranjan PattnaikiD· 2 shared David M. GammiD· 2 shared Krishanu SahaiD· 2 shared Meha Kabra· 2 shared Shaoqin GongiD· 2 shared Allison SpillaneiD· 1 shared Cole O. Theisen· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenomics

Amr A. AbdeenORCID

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2 papers

Recent·Most cited

GenomicsNature CommunicationsPeer-reviewedAug 13, 2026

Genome-Wide CRISPR Screening Identifies Cellular Factors Controlling Nonviral Genome Editing Efficiency

Shivani Saxena, Meha Kabra, Amr A. Abdeen…·Krishanu Saha

The paper uses CRISPR screening to identify genes that enhance nonviral genome editing efficiency in human cells, finding six genes that increase editing efficiency by up to five-fold.

DOI 10.1038/s41467-026-76350-5

humanCRISPR screen

𝕏 PostBluesky

GeneticsbioRxivPreprintJul 12, 2022

Nonviral base editing of KCNJ13 mutation preserves vision in an inherited retinal channelopathy

Meha Kabra, Pawan Kumar Shahi, Yuyuan Wang…·Bikash Ranjan Pattnaik

This paper demonstrates nonviral base editing of a KCNJ13 mutation in a mouse model of retinal degeneration, preserving vision through functional rescue of Kir7.1 channels.

2 citations

mouseexperimental assay

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