Confined T cell migration controls programmed cell death 1 expression
Yunus Alapan, Jaehoon Kim, Kiyoon Min, Alexander Shih, Samuel N. Lucas, Taehee Yoon, Paul A. Archer, Heather K. Lin, Ruby Freeman, Megen C Wittling, Megan M. Wyatt, Chrystal Mary Paulos, Sarwish Rafiq, Susan Napier Thomas
The paper shows that confined T cell migration through pores reduces programmed cell death 1 expression via ubiquitin-mediated degradation, enhancing T cell function and correlating with disease outcomes in melanoma.
bioRxiv · Jul 9, 2026 · PreprintImmunology