Author

Xiangru Li

Emory UniversityORCID 0009-0002-1303-6785Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Christina MichalskiiD· 2 shared Shaojun YuiD· 2 shared Weibo NiuiD· 2 shared Zhaohui Steve QiniD· 2 shared Zhexing WeniD· 2 shared Arman JahangiriiD· 1 shared Bingshan LiiD· 1 shared Bradley D. PearceiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Christina MichalskiORCID

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2 papers

Recent·Most cited

Synaptic microRNA dysregulation orchestrates aberrant glutamatergic transmission in a human neuronal model of 22q11.2 deletion syndrome

Weibo Niu, Jidong Guo, Ximing Ran, David Parker, Xiangru Li, Shaojun Yu, Sidney Imes, Ryan H. Purcell, Christina Michalski, Eric Guo, Sophia Y Jiang, Ethan Xu, Gary Jonathan Bassell, Jennifer Gladys Mulle, Opal Ousley, , Zhexing Wen

This study identifies dysregulated synaptic microRNAs in 22q11DS neurons that drive aberrant glutamatergic transmission and synaptic plasticity, linking genetic deletion to psychosis risk.

bioRxiv · Oct 15, 2026 · PreprintNeuroscience

Longitudinal multi-omics reveals pathogenic TSC2 variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex

Weibo Niu, Shaojun Yu, Xiangru Li, Zhen Wang, Rui Chen, Christina Michalski, Arman Jahangiri, Youssef M. Zohdy, Joshua J. Chern, Ted J. Whitworth, Jianjun Wang, Jie Xu, Ying Zhou, Zhaohui Steve Qin, Bingshan Li, , Zhexing Wen

This study uses longitudinal multi-omics analysis of cortical organoids to show that TSC2 pathogenic variants disrupt neurodevelopmental trajectories, leading to synaptic and mitochondrial dysfunction.

bioRxiv · Oct 7, 2024 · PreprintNeuroscience