Author

Weibo Niu

Emory UniversityORCID 0000-0002-8395-3442Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Zhexing WeniD· 4 shared Christina MichalskiiD· 2 shared Gary Jonathan BasselliD· 2 shared Jennifer Gladys MulleiD· 2 shared Joseph F. CubellsiD· 2 shared Ryan H. PurcelliD· 2 shared Shaojun YuiD· 2 shared Xiangru LiiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Zhexing WenORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Synaptic microRNA dysregulation orchestrates aberrant glutamatergic transmission in a human neuronal model of 22q11.2 deletion syndrome

Weibo Niu, Jidong Guo, Ximing Ran, David Parker, Xiangru Li, Shaojun Yu, Sidney Imes, Ryan H. Purcell, Christina Michalski, Eric Guo, Sophia Y Jiang, Ethan Xu, Gary Jonathan Bassell, Jennifer Gladys Mulle, Opal Ousley, , Zhexing Wen

This study identifies dysregulated synaptic microRNAs in 22q11DS neurons that drive aberrant glutamatergic transmission and synaptic plasticity, linking genetic deletion to psychosis risk.

bioRxiv · Oct 15, 2026 · PreprintNeuroscience

Convergent effects of neurodevelopmental disorder-associated variants at mitochondria

Maxine I. Robinette, Jada B. Gundy, Xinyan Leng, Duc Duong, Anantharaman Shantaraman, Liang Shi, Elizabeth Arnulfo Candelario, Anson David Sing, Shubhangi Vibhor Garg, Weibo Niu, Nicholas T. Seyfried, Steven A. Sloan, Zhexing Wen, Joseph F. Cubells, Erica Nichole Duncan, , Ryan H. Purcell

The paper investigates how neurodevelopmental disorder-associated variants affect mitochondrial proteins and finds convergent effects on mitochondrial translation in two high-risk CNVs.

bioRxiv · Feb 27, 2026 · PreprintNeuroscience

Longitudinal multi-omics reveals pathogenic TSC2 variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex

Weibo Niu, Shaojun Yu, Xiangru Li, Zhen Wang, Rui Chen, Christina Michalski, Arman Jahangiri, Youssef M. Zohdy, Joshua J. Chern, Ted J. Whitworth, Jianjun Wang, Jie Xu, Ying Zhou, Zhaohui Steve Qin, Bingshan Li, , Zhexing Wen

This study uses longitudinal multi-omics analysis of cortical organoids to show that TSC2 pathogenic variants disrupt neurodevelopmental trajectories, leading to synaptic and mitochondrial dysfunction.

bioRxiv · Oct 7, 2024 · PreprintNeuroscience

Non-Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High-Content Imaging

Seleipiri Charles, Emily Jackson, Gongchen Sun, Ying Zhou, Benjamin Siciliano, Weibo Niu, Haejun Han, Arina A. Nikitina, Melissa Lambeth Kemp, Zhexing Wen, Hang Lu

This paper develops a mesofluidic bioreactor platform with high-content imaging for non-invasive quality control of brain organoids, improving their development and reducing cell death.

Advanced Materials Technologies · Aug 31, 2024Peer-reviewedBioengineering