Author

Xiangna Guan

Center for Life SciencesORCID 0009-0002-1397-6910Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Chi HeiD· 1 shared Hong WuiD· 1 shared Hui ShiiD· 1 shared Liuqing YangiD· 1 shared Tantan Wang· 1 shared Xuebin LiaoiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperImmunology

Chi HeORCID

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1 paper

Recent·Most cited

Enhance Memory CD8+ T Cell Formation via Downregulation of Hematopoietic Progenitor Kinase 1 and Sustained Mitochondrial Fitness

Liuqing Yang, Tantan Wang, Xiangna Guan, Chi He, Hui Shi, Hong Wu, Xuebin Liao

This study shows that HPK1 deletion enhances memory CD8+ T cell formation and antitumor activity by promoting metabolic reprogramming and mitochondrial fitness.

bioRxiv · Apr 10, 2025 · PreprintImmunology