Hong Wu

This study shows KDM5A enhances MHC-I antigen presentation and improves antitumor immunity in response to PD-1 checkpoint blockade in cancer patients.

This study shows that HPK1 deletion enhances memory CD8+ T cell formation and antitumor activity by promoting metabolic reprogramming and mitochondrial fitness.

The paper identifies high-risk factors and actionable targets in T-ALL through integrated genomic and transcriptomic analyses of 165 patients, finding RAS pathway and PTEN mutations as poor survival factors and potential therapeutic targets.

The paper identifies 3D genome alterations and enhancer hijacking mechanisms in T-lineage acute lymphoblastic leukemia (T-ALL) using integrated analyses of 18 patients and 4 controls.