Author

Jiaxuan Xu

Peking UniversityORCID 0009-0002-1762-9123Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Lei CheniD· 2 shared Jiahe ZangiD· 1 shared Miao WeiiD· 1 shared Weiyu TaoiD· 1 shared Wenjun GuoiD· 1 shared Xiao Dong HeiD· 1 shared Xiaoyu LiuiD· 1 shared Yuezhou CheniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Lei ChenORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedFeb 10, 2025

✦ In-depth digest

Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1

Wenjun Guo, Miao Wei, Yunfeng Li…·Lei Chen

Cryo-EM structures of human URAT1 with urate, benzbromarone, or verinurad (3.0 to 3.3 Å) reveal a rocker-switch transport cycle and inhibitors that lock the inward-facing state.

35 citationstop 1%

humanprotein structure

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BiophysicsCell DiscoveryPeer-reviewedJan 13, 2025

Structure of small HBV surface antigen reveals mechanism of dimer formation

Xiao Dong He, Yunlu Kang, Weiyu Tao…·Lei Chen

The paper determines the structure of HBsAg at 3.6 Å resolution, revealing how monomers form dimers as the basic unit of SVPs.

14 citationstop 2%

structural biologyexperimental assay

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