BiochemistryNature CommunicationsPeer-reviewed
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Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1
Wenjun Guo, Miao Wei, Yunfeng Li…·Lei Chen
Cryo-EM structures of human URAT1 with urate, benzbromarone, or verinurad (3.0 to 3.3 Å) reveal a rocker-switch transport cycle and inhibitors that lock the inward-facing state.
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