Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility
Kierstin L. Webster, Armando A. Puente, Jacob R. Enriquez…·Raghavendra G. Mirmira
This study identifies sex-specific islet responses to inflammation and shows that estrogen reduces inflammatory signaling and promotes immune tolerance in beta cells, contributing to sex differences in type 1 diabetes susceptibility.