Bobbie‐Jo Webb‐Robertson

Coordinated expansion of CD163⁺ monocytes and immature CD177⁺ neutrophils marks severe neurotoxicity after CD19 CAR T cell therapy

The paper identifies CD163+ monocytes and immature CD177+ neutrophils as markers of severe neurotoxicity after CD19 CAR T cell therapy through multi-omics profiling.

Carbamylome analysis reveals regulatory roles for lysine carbamylation in β-cell glycolytic and insulin-processing enzymes

The paper identifies carbamylation as a regulatory modification in β-cell metabolism and insulin processing in T1D by analyzing proteomic changes in NOD and MIN6 cells.

Assessing extracellular vesicle proteins as predictive biomarkers for developing type 1 diabetes

This study evaluates plasma extracellular vesicle proteomics for identifying predictive biomarkers of type 1 diabetes development, finding 448 differentially abundant proteins and a 0.81 AUC in predicting islet autoimmunity.

Reference-free compound identification using computational prediction of molecular properties and multi-dimensional spectrometric measurements: a fentanyl case study

This paper identifies unknown molecules without reference libraries by combining computational predictions with spectrometric data, achieving exact identifications in a fentanyl case study.

A Benchmarking Study of Feature Screening Approaches Across Omics Classification Settings

This paper benchmarks feature screening methods for omics data classification, finding BcorSIS to be the most effective and efficient across various datasets.

Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility

This study identifies sex-specific islet responses to inflammation and shows that estrogen reduces inflammatory signaling and promotes immune tolerance in beta cells, contributing to sex differences in type 1 diabetes susceptibility.

Associations between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach

This study investigates changes in human milk composition after SARS-CoV-2 infection or vaccination using multi-omics approaches, finding greater compositional changes post-infection than post-vaccination.

Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images

This paper improves axon segmentation in light-sheet microscopy images by fine-tuning the TrailMap model with expert-labeled data, achieving better recall and adjusted F1-score.

From plants to ants: Fungal modification of leaf lipids for nutrition and communication in the leaf-cutter ant fungal garden ecosystem

This study uses lipidomics to analyze leaf-cutter ant fungal gardens, showing lipids play roles in energy transfer and inter-kingdom communication through differential fatty acid responses.

The role of islet lipid composition remodeling in regulation of beta-cell death via ADP-ribosyl-acceptor glycohydrolase ARH3 signaling in insulitis

The paper investigates lipid composition changes in insulitis models and identifies ARH3 as a regulator of beta-cell apoptosis through PLA2G6 signaling.

The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides new insights into the genetics of type 1 diabetes

This study shows that pro-inflammatory cytokines reveal plasticity in β-cell regulatory landscapes and identify T1D-associated variants disrupting cytokine-responsive enhancers.