Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage
Ana Lago-Maciel, Jéssica C. Soares, Jan Zarzycki, Charles J. Buchanan, Tristan Reif-Trauttmansdorff, Frederik V. Schmidt, Stefano Lometto, Nicole Paczia, Jan M. Schuller, D. Flemming Hansen, Gabriella T. Heller, Simone Prinz, Georg K. A. Hochberg, Antonio J. Pierik, Johannes G. Rebelein
This study presents the first molecular structure of methylthio-alkane reductase, revealing metalloclusters that inform its function and evolutionary relationship to nitrogenases.
Nature Catalysis · Oct 23, 2025Peer-reviewedBiochemistry