Antimicrobial activity of polymyxin A, and characterisation of the cognate biosynthetic gene cluster within the genome of the producing Paenibacillus polymyxa.
Amy McLeman, Alexander D. H. Kingdon, Robin Hoeven, George Taylor, Ellie Allman, Issra Bulgasim, Claudia McKeown, Richard N. Goodman, Sabrina John Moyo, Adam Paul Roberts
This study isolates a Paenibacillus polymyxa strain, characterizes its polymyxin A biosynthetic gene cluster, and finds that resistance genes mcr-1 and mcr-4 confer resistance to polymyxin A.
bioRxiv · Jun 1, 2026 · PreprintMicrobiology