Adam Paul Roberts

The paper uses shotgun metagenomic sequencing to analyze microbial communities and antimicrobial resistance genes across five urban surface types in Liverpool, finding distinct microbial and resistance profiles with higher ARG abundance on frequently contacted surfaces.

This study examines how sub-inhibitory concentrations of ceftriaxone, combined with colistin and kanamycin, affect intracellular transposition in Escherichia coli, identifying thresholds for environmental impact.

This study shows 3-BP covalently inhibits NDM-1 and NDM-5 MBLs, restoring carbapenem activity against resistant bacterial strains.

This study compares laboratory evolution of piperacillin-tazobactam resistance in Klebsiella grimontii with within-patient resistance evolution, showing that small population bottlenecks reproduce key resistance mechanisms observed in clinical isolates.

This study isolates a Paenibacillus polymyxa strain, characterizes its polymyxin A biosynthetic gene cluster, and finds that resistance genes mcr-1 and mcr-4 confer resistance to polymyxin A.

This study tracks the in vivo evolution of an antibiotic-resistant E. coli strain in an infant gut, showing a reduction in IS26-mediated resistance gene arrays without fitness or susceptibility changes.

The paper uses whole-genome sequencing to study ESBL-Ec transmission networks in rural Malawi, finding high colonization rates and multi-household spread.

The paper identifies novel β-lactamase genes from environmental Pseudomonas spp. isolates, showing their resistance properties and potential clinical relevance.

This study identifies freshwater snail faeces as environmental reservoirs of antimicrobial resistance genes across multiple countries using metagenomic analysis.

This study compares genomic and phenotypic differences between faecal and bloodstream isolates from the same patients to understand pathogenesis of Gram-negative bloodstream infections.

This study uses shotgun metagenomic analysis of oral saliva from children with noma to identify Treponema sp. A as a novel disease-associated organism and highlights antimicrobial resistance concerns.

The paper compares genomic data from blood and faecal isolates of E. coli and K. pneumoniae from neonatal patients to determine if bloodstream infections originated from the gastrointestinal tract.

This paper develops a DNA extraction protocol for mycobacteria that produces high-quality sequencing data without requiring cold chain storage or toxic chemicals.