Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits
Christal N. Davis, Sylvanus Toikumo, Alexander Samir Hatoum…·Penn Medicine BioBank
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University of PennsylvaniaORCID 0009-0002-3093-3947Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
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Christal N. Davis, Sylvanus Toikumo, Alexander Samir Hatoum…·Penn Medicine BioBank
Christal N. Davis, Yousef Khan, Zachary Piserchia…·Henry R. Kranzler
The paper investigates the genetic overlap between educational attainment and substance use traits, finding distinct genetic patterns for cognitive and non-cognitive components of education.
Sylvanus Toikumo, Christal N. Davis, Zeal Jinwala…·Henry R. Kranzler
This study identifies 343 genetic loci for chronic pain in 1.2 million individuals, revealing pleiotropy with psychiatric disorders and brain structures.
Christal N. Davis, Yousef Khan, Sylvanus Toikumo…·Henry R. Kranzler
The paper integrates HiTOP and RDoC frameworks to identify shared and distinct biological mechanisms of externalizing and internalizing psychopathology using multi-omics approaches.
Christal N. Davis, Yousef Khan, Sylvanus Toikumo…·Henry R. Kranzler
The paper uses genomic structural equation modeling to identify the genetic architecture of externalizing and internalizing psychopathology, finding a moderate genetic correlation and shared causal variants.
Yousef Khan, Christal N. Davis, Zeal Jinwala…·Rachel L. Kember
This paper combines transdiagnostic and disorder-level GWAS to enhance genetic risk profiles for psychiatric disorders in multi-ancestry samples, identifying novel SNPs and shared genetic variance.