EGR3 Deletion Rescues Developmental and Epileptic Encephalopathy in Kcna1-null Mice
Arindam Ghosh Mazumder, Saifina Karedia, Nandani Adhyapak, Catharina Schimer, John Samuel Bass, Jessica L. Kamen, Miranda J. Jankovic, Qinglong Miao, Amelia L. Gallitano, Alexander B. Saltzman, Antrix Jain, Anna Malovannaya, Edward Glasscock, Isamu Aiba, Jeffrey L. Noebels, Vaishnav Krishnan
This study shows that deleting EGR3 in Kcna1-null mice rescues seizures, behavior, and brain pathology, linking early seizures to long-term transcriptional changes.
bioRxiv · Jun 7, 2025 · PreprintNeuroscience