Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroids
Joscelyn C. Mejías, Nazmiye Celik, Sushma Nagaraj, Katlin B. Stivers, Helen Hieu Nguyen, A. Shri Ramanujam, Frank Haoning Yu, Maria A Browne, Rachel Michel, Md Soriful Islam, Christopher Cherry, Alexandra N. Rindone, Abigail Fennell, Chanhong Min, Bhuchitra Singh, , Jennifer H. Elisseeff
This study identifies distinct senescent cell populations in human fibroids and shows their role in ECM remodeling and vascular dysfunction through single-cell RNA sequencing and functional analysis.
bioRxiv · Aug 7, 2026 · PreprintCell Biology