Sushma Nagaraj

SEngEAR is a web platform for annotating senescent cells, visualizing communication networks, and comparing senescence signatures across datasets and contexts.

This study identifies distinct senescent cell populations in human fibroids and shows their role in ECM remodeling and vascular dysfunction through single-cell RNA sequencing and functional analysis.

The paper identifies distinct fibroblast and perivascular senescence subtypes in fibrosis using single-cell and spatial transcriptomics, showing their spatial organization and roles in fibrosis progression.

The paper introduces dominoSignal, a software tool that statistically tests differential cell signaling from single-cell data to infer changes in cell-cell communication networks.

The paper identifies Treg clonal expansion and immunosuppressive functions in fibrosis induced by synthetic implants, showing their role in modulating stromal cell behavior.

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

This study shows that age-related changes in the lineage composition of the enteric nervous system affect gut health, with mesoderm-derived neurons becoming dominant and functional effects on intestinal motility that can be reversed by GDNF.

The paper analyzes mtDNA from individuals with biparental transmission and finds no evidence of intermolecular recombination, supporting strict maternal inheritance.