Anna Ruta

Age and sex alter the immune response in a chronic fibrosis model via changes in T cell and macrophage phenotype

This study shows age and sex affect fibrosis and immune response in a mouse model of implant-induced chronic inflammation through changes in T cell and macrophage phenotypes.

Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroids

This study identifies distinct senescent cell populations in human fibroids and shows their role in ECM remodeling and vascular dysfunction through single-cell RNA sequencing and functional analysis.

Distinct fibroblast and perivascular senotypes define spatial niches that regulate fibrosis

The paper identifies distinct fibroblast and perivascular senescence subtypes in fibrosis using single-cell and spatial transcriptomics, showing their spatial organization and roles in fibrosis progression.

γδ17 T cell-stromal networks modulate matrix composition and vascularity in foreign body response

This study shows that γδ17 T cells influence fibrosis by altering ECM composition and vascularity through interactions with stromal cells.

Tissue Injury and Biomaterial Treatment Modulate Tumor Growth and Response to Immunotherapy

This study shows that tissue injury accelerates tumor growth and reduces response to immunotherapy in mice, but biomaterials that enhance wound healing can improve outcomes and ICB response.

Immune checkpoint inhibitors amplify type 2 immune mediated repair bypro-regenerative scaffolds

This study shows immune checkpoint inhibitors enhance type 2 immunity and regeneration in ECM-treated wounds by promoting Treg/TH2 plasticity and pro-regenerative macrophages.

Regulatory T cells clonally expand and contribute to stromal cell function in fibrotic response to synthetic implants

The paper identifies Treg clonal expansion and immunosuppressive functions in fibrosis induced by synthetic implants, showing their role in modulating stromal cell behavior.

Antibiotic-induced microbiota depletion impairs the pro-regenerative response to a biological scaffold in mice

This study shows antibiotic-induced microbiota depletion in mice impairs the pro-regenerative immune response to a biological scaffold, reducing myocyte regeneration and increasing fibrosis.

Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant

This study shows that gut microbiota dysbiosis from enteric infection increases immune cell recruitment to a distant biomaterial implant, affecting the foreign body response.