Author

Heli Jeskanen

University of Eastern FinlandORCID 0009-0002-4783-7951Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

Henna MartiskaineniD· 3 shared Mari TakaloiD· 3 shared Roosa-Maria WillmaniD· 3 shared Sami HeikkineniD· 3 shared Annakaisa HaapasaloiD· 2 shared Inka Kervinen· 2 shared Mikko O. HiltuneniD· 2 shared Teemu KuulasmaaiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersNeuroscience

Henna MartiskainenORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintSep 22, 2025

The protective PLCG2 variants delay Alzheimer's disease onset age in APOE ϵ4 carriers

Heli Jeskanen, Sami Heikkinen, Inka Kervinen…·Mikko O. Hiltunen

The paper examines how protective PLCG2 variants delay Alzheimer's onset in APOE ε4 carriers and identifies associated plasma biomarkers.

DOI 10.1101/2025.09.22.25336304

humanproteomics

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NeurosciencebioRxivPreprintSep 12, 2024

Protective variant in PLCgamma2 mitigates Alzheimer's disease associated pathology via enhancing beneficial microglia functions

Mari Takalo, Heli Jeskanen, Taisia Rõlova…·Mikko Hiltunen

This study shows that the PLCgamma2-P522R variant reduces beta-amyloid pathology and enhances microglial function in AD models, suggesting an anti-ageing mechanism.

DOI 10.1101/2024.09.12.612207

mouseproteomics

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NeurosciencebioRxivPreprintApr 29, 2024

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks

Audrey Coulon, Florian Rabiller, Mari Takalo…·Jean‐Charles Lambert

This study shows that PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease-related markers in neurons.

3 citations

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