BioengineeringbioRxivPreprint
LNP-mediated BCL11A Editing Corrects Sickling Phenotypes and Preserves HSPC Fitness Compared to Electroporation
Yaw Ofosu Nyansa Ansong‐Ansongton, Corynne Stéphanie Ahouéfa Adanho, Utku Goreke…·David N. Nguyen
This study compares LNP and electroporation for delivering CRISPR to HSPCs, finding LNPs provide better cell viability and HbF induction with lower toxicity.
DOI 10.64898/2026.08.26.747413