Author

Harini Shandilya

AstraZeneca (United States)ORCID 0009-0002-6925-9785Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Andrew B. DippeliD· 1 shared Gilad KaplaniD· 1 shared Giuliana VozzaiD· 1 shared Jeffrey A. RuffoloiD· 1 shared Jeffrey J. GrayiD· 1 shared Keith W. RickertiD· 1 shared Mark Rowland HutchinsoniD· 1 shared Melissa M. DamschroderiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Andrew B. DippelORCID

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1 paper

Recent·Most cited

Enhancement of antibody thermostability and affinity by computational design in the absence of antigen

Mark Rowland Hutchinson, Jeffrey A. Ruffolo, Nantaporn Haskins, Michael J. Iannotti, Giuliana Vozza, Tony Pham, Nurjahan Mehzabeen, Harini Shandilya, Keith W. Rickert, Rebecca Croasdale-Wood, Melissa M. Damschroder, Ying Hui Fu, Andrew B. Dippel, Jeffrey J. Gray, Gilad Kaplan

This study uses DeepAb to design antibody variants with enhanced stability and affinity without antigen information, showing 91% and 94% improvements in thermal/colloidal stability and affinity, respectively.

mAbs · Jun 20, 2024Peer-reviewedMolecular Biology