CD19-CAR T-cell therapy resets the EBV+ autoreactive B cell repertoire in autoimmune disease
Ya'el Courtney, Mahesh Pandit, Laura S van Dam, Shady Younis, Sajede Rasouli, Mengrui Zhang, Yashaar Chaichian, Shima Parsafar, Tobias V Lanz, Eline Arends, Cees van Kooten, Y. K. Onno Teng, Melanie Hagen, Andreas Wirsching, Fabian Muller, , William H Robinson
This study shows CD19-CAR T-cell therapy depletes EBV+ autoreactive B cells and resets their repertoire, leading to sustained remission, while rituximab does not.
bioRxiv · Nov 2, 2026 · PreprintImmunology