Shady Younis

This study shows CD19-CAR T-cell therapy depletes EBV+ autoreactive B cells and resets their repertoire, leading to sustained remission, while rituximab does not.

The paper identifies four synovial transcriptional clusters in knee OA linked to cartilage degeneration severity through bulk and single-cell RNA-seq analyses.

The paper shows EBV infects and reprograms autoreactive B cells into antigen-presenting cells in MS, driving pathogenic T cell responses.

This study identifies elevated oxidative stress in both ME/CFS and Long COVID patients through blood cell analysis, suggesting shared molecular mechanisms and potential therapeutic targets.

This study identifies ZC3H11A as a regulator of polyadenylation of viral transcripts through its interaction with PABPN1 and mRNA.

This study investigates ZBED6's role in mouse myoblasts using gene editing, RNAseq, and proteomics, showing ZBED6 regulates IGF2 through a specific binding site, affecting mitochondrial activity and myogenesis.