Author

Cees van Kooten

Leiden University Medical CenterORCID 0000-0002-6257-0899Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Aline BozeciD· 1 shared Andreas MackenseniD· 1 shared Andreas WirschingiD· 1 shared Annemarie M. A. de Graaf· 1 shared Dorottya K. de VriesiD· 1 shared Elena Sánchez‐LópeziD· 1 shared Eline ArendsiD· 1 shared Fabian MulleriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Aline BozecORCID

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2 papers

Recent·Most cited

CD19-CAR T-cell therapy resets the EBV+ autoreactive B cell repertoire in autoimmune disease

Ya'el Courtney, Mahesh Pandit, Laura S van Dam, Shady Younis, Sajede Rasouli, Mengrui Zhang, Yashaar Chaichian, Shima Parsafar, Tobias V Lanz, Eline Arends, Cees van Kooten, Y. K. Onno Teng, Melanie Hagen, Andreas Wirsching, Fabian Muller, , William H Robinson

This study shows CD19-CAR T-cell therapy depletes EBV+ autoreactive B cells and resets their repertoire, leading to sustained remission, while rituximab does not.

bioRxiv · Nov 2, 2026 · PreprintImmunology

Normothermic human kidney preservation drives iron accumulation and ferroptosis

Marlon J.A. de Haan, Marleen E Jacobs, Annemarie M. A. de Graaf, Roan H van Scheppingen, Rico J. E. Derks, Dorottya K. de Vries, Jesper Kers, Ian P.J. Alwayn, Cees van Kooten, Elena Sánchez‐López, Martin A. Giera, Marten A. Engelse, Ton J. Rabelink

This study shows that normothermic kidney preservation with red blood cells causes iron accumulation and ferroptosis, leading to kidney injury, and suggests alternatives to mitigate these effects.

Nature Communications · Jul 1, 2025Peer-reviewedPhysiology