HIV Env trimers elicit NHP apex cross-neutralizing antibodies mimicking human bNAbs
Javier Guenaga, Mónika Ádori, Shridhar Bale, Swastik Phulera, Ioannis Zygouras, Fabian-Alexander Schleich, Xaquín Castro Dopico, Sashank Agrawal, Miyo Ota, Richard Wilson, Jocelyn Cluff, Tamar Dzvelaia, Marco Mandolesi, Agnes A. Walsh, Mariane B. Melo, , Richard T. Wyatt
This study shows that HIV Env trimers coupled to liposomes induce cross-neutralizing antibodies in NHPs that mimic human bNAbs targeting the Env trimer apex.
bioRxiv · Sep 19, 2025 · PreprintImmunology