Gunilla B. Karlsson Hedestam

This study identifies two antibody classes that neutralize pneumovirus by targeting a conserved epitope, revealing distinct mechanisms of action through structural and functional analyses.

The paper presents a high-resolution analysis of human IGH germline gene diversity across 2,486 individuals from 25 global populations, revealing population-specific patterns and disease-linked haplotypes.

This study shows that HIV Env trimers coupled to liposomes induce cross-neutralizing antibodies in NHPs that mimic human bNAbs targeting the Env trimer apex.

This study shows that macaques can elicit human-like broadly neutralizing antibodies against influenza HA stem regions, with similar immunogenetic and structural features.

The paper shows that genetic variation in human immunoglobulin genes affects antibody responses to influenza HA, informing vaccine design to cover diverse populations.

This paper introduces CHMMAIRRa, a hidden Markov model to detect PCR chimeras in AIRR-seq data, incorporating somatic hypermutation and germline references.

This paper introduces a semi-supervised Bayesian mixture model for joint batch correction and classification, showing improved performance on low-dimensional data compared to existing methods.

This paper identifies an alpaca nanobody that neutralizes SARS-CoV-2 by blocking the ACE2 receptor interaction.