Xaquín Castro Dopico

HIV Env trimers elicit NHP apex cross-neutralizing antibodies mimicking human bNAbs

This study shows that HIV Env trimers coupled to liposomes induce cross-neutralizing antibodies in NHPs that mimic human bNAbs targeting the Env trimer apex.

Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies

The paper shows that genetic variation in human immunoglobulin genes affects antibody responses to influenza HA, informing vaccine design to cover diverse populations.

Antigen affinity and site of immunization dictate B cell recall responses

This study shows that antigen affinity and immunization site influence B cell recall responses, with low affinity boosts leading to higher SHM but fewer memory B cells in secondary GCs.

A semi-supervised Bayesian mixture modelling approach for joint batch correction and classification

This paper introduces a semi-supervised Bayesian mixture model for joint batch correction and classification, showing improved performance on low-dimensional data compared to existing methods.

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

The paper identifies autoimmune disease candidate genes by integrating promoter capture Hi-C data with genetic associations in activated CD4+ T cells.