Swastik Phulera

Sequential vaccination matures VRC01-class HIV-1 neutralizing antibodies in humans

This study shows that sequential vaccination can mature VRC01-class B cells into antibodies that neutralize a broad range of HIV-1 viruses.

Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation

This study improves HIV broadly neutralizing antibodies through multistate engineering, resulting in enhanced breadth and potency against diverse Env variants.

HIV Env trimers elicit NHP apex cross-neutralizing antibodies mimicking human bNAbs

This study shows that HIV Env trimers coupled to liposomes induce cross-neutralizing antibodies in NHPs that mimic human bNAbs targeting the Env trimer apex.

Virus glycoprotein nanodisc platform for vaccine design

The paper presents a nanodisc platform for assembling transmembrane glycoproteins into vaccine candidates, demonstrating its utility in HIV vaccine development through structural and functional analyses.

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2 heterotrimeric GABAA receptor in complex with GABA illuminates mechanism of receptor assembly and agonist binding

The paper presents the cryo-EM structure of a triheteromeric GABAA receptor complexed with GABA, revealing mechanisms of receptor assembly and agonist binding.