BiophysicsbioRxivPreprint
Systematic DNA nicking reveals the structural logic of protein recognition
Yumi Minyi Yao, Michael O’Hagan, Karn Onoon…·Ariel Afek
This study introduces PIC-NIC, a method to systematically perturb DNA binding sites without altering base sequences, revealing how DNA backbone structure influences transcription factor binding.
DOI 10.1101/2025.06.30.662289