Ariel Afek

EpiBinder predicts cell-type-specific TF binding by integrating DNA sequence and epigenetic data, improving prediction accuracy and providing interpretability.

This study shows IRF1 regulates antiviral immunity through both cytokine signaling and direct promoter binding, affecting gene expression in a context-dependent manner.

This study introduces PIC-NIC, a method to systematically perturb DNA binding sites without altering base sequences, revealing how DNA backbone structure influences transcription factor binding.

This study shows that TMPRSS2-ERG fusion promotes resistance to antiandrogens by interacting with GR, suggesting combined GR and AR inhibition could benefit tERG-positive prostate cancer patients.