Miguel Ángel Peña-Ortiz

Spared cognitive and social function following perinatal ablation of ATRX despite transient microglia dysregulation

This study shows that perinatal loss of ATRX in microglia leads to chronic reactivity and turnover but does not affect cognitive or social functions.

Astrocytic Chromatin Remodeler ATRX Gates Hippocampal Memory Consolidation through Metabolic and Synaptic Regulation

This study shows that astrocytic ATRX loss leads to neuronal dysfunction and long-term memory deficits through metabolic and synaptic pathway dysregulation.

Viral mimicry and memory deficits upon microglial deletion of ATRX

This study shows that deleting ATRX in microglia disrupts chromatin structure, leading to viral mimicry and cognitive deficits in memory tasks.

Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination

This study shows that ATRX loss in oligodendrocyte progenitor cells causes myelination deficits and promotes astrocyte-like features, highlighting ATRX's role in myelination and glial cell fate.

Selective isolation of mouse glial nuclei optimized for reliable downstream omics analyses

This paper describes a method for isolating mouse glial nuclei with minimal processing steps, enabling reliable downstream omics analyses like ATAC-seq and RNA-seq.