Nathalie G. Bérubé

This study shows that NRXN1 deletion alters the H3K27me3 landscape and disrupts neural induction through epigenetic changes and spliceosome dysregulation.

This study shows that perinatal loss of ATRX in microglia leads to chronic reactivity and turnover but does not affect cognitive or social functions.

This study uses MRI to show that ATRX deficiency in mice leads to brain structural changes linked to autism-like behaviors, including sex-specific microcephaly and altered hippocampal and cortical volumes.

This study shows that astrocytic ATRX loss leads to neuronal dysfunction and long-term memory deficits through metabolic and synaptic pathway dysregulation.

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

This study shows that deleting ATRX in microglia disrupts chromatin structure, leading to viral mimicry and cognitive deficits in memory tasks.

This study shows that ATRX loss in oligodendrocyte progenitor cells causes myelination deficits and promotes astrocyte-like features, highlighting ATRX's role in myelination and glial cell fate.

This paper describes a method for isolating mouse glial nuclei with minimal processing steps, enabling reliable downstream omics analyses like ATAC-seq and RNA-seq.

This study shows that deleting Atrx in mouse forebrain neurons causes male-specific spatial memory deficits linked to miR-137 dysregulation and synaptic abnormalities.