Author

Yan Yi Jiang

Western UniversityORCID 0000-0002-1507-8690Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Nathalie G. BérubéiD· 3 shared Sarfraz ShafiqiD· 3 shared Megan E. RowlandiD· 2 shared Miguel Ángel Peña-OrtiziD· 2 shared Vanessa DumeauxiD· 2 shared Alireza Ghahramani· 1 shared Arsham GhahramaniiD· 1 shared Dalila PintoiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersNeuroscience

Nathalie G. BérubéORCID

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4 papers

Recent·Most cited

Viral mimicry and memory deficits upon microglial deletion of ATRX

Sarfraz Shafiq, Arsham Ghahramani, K. Mansour, Miguel Ángel Peña-Ortiz, Julia Kathryn Sunstrum, Yan Yi Jiang, Megan E. Rowland, Wataru Inoue, Nathalie G. Bérubé

This study shows that deleting ATRX in microglia disrupts chromatin structure, leading to viral mimicry and cognitive deficits in memory tasks.

bioRxiv · May 7, 2024 · PreprintNeuroscience

Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination

Megan E. Rowland, Yan Yi Jiang, Sarfraz Shafiq, Alireza Ghahramani, Miguel Ángel Peña-Ortiz, Vanessa Dumeaux, Nathalie G. Bérubé

This study shows that ATRX loss in oligodendrocyte progenitor cells causes myelination deficits and promotes astrocyte-like features, highlighting ATRX's role in myelination and glial cell fate.

bioRxiv · Sep 15, 2022 · PreprintNeuroscience

Cell type-specific isolation and transcriptomic profiling informs glial pathology in human temporal lobe epilepsy

Jessica Tomé-García, German Nudelman, Zarmeen M. Mussa, Elodia Caballero, Yan Yi Jiang, Kristin G. Beaumont, Ying‐Chih Wang, Robert Sebra, Schahram Akbarian, Dalila Pinto, Elena Zaslavsky, Nadejda M. Tsankova

The paper isolates and profiles cell types in human TLE samples, revealing dysregulated pathways and an immature glial phenotype.

bioRxiv · Dec 11, 2020 · PreprintNeuroscience

Atrx deletion in neurons leads to sexually-dimorphic dysregulation of miR-137 and spatial learning and memory deficits

Renee J. Tamming, Vanessa Dumeaux, Yan Yi Jiang, Sarfraz Shafiq, Luana Langlois, Jacob Ellegood, Lily R. Qiu, Jason P. Lerch, Nathalie G. Bérubé

This study shows that deleting Atrx in mouse forebrain neurons causes male-specific spatial memory deficits linked to miR-137 dysregulation and synaptic abnormalities.

Cell Reports · Jun 1, 2020Peer-reviewedNeuroscience