Author

Edward L. LaGory

Amgen (United States)ORCID 0000-0002-0552-1695Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Alicia N. SchepiD· 1 shared Amato J. GiacciaiD· 1 shared Danielle PruittiD· 1 shared David J. ShermaniD· 1 shared Hani ChoudhryiD· 1 shared Howard Y. ChangiD· 1 shared Ingrid C. RulifsoniD· 1 shared Jiansong Xie· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Alicia N. SchepORCID

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3 papers

Recent·Most cited

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

David J. Sherman, Lei Liu, Edward L. LaGory, Preston Fordstrom, Danielle Pruitt, Jose Barreda, Joy G. Cagmat, Jiansong Xie, John Ferbas, Ingrid C. Rulifson, Raymond J. Deshaies

This paper identifies PNPLA3-I148M as a neomorphic variant that impairs ApoB secretion and lipid metabolism, contributing to fatty liver disease.

Cell Reports · Oct 1, 2025Peer-reviewedCell Biology

A dynamic HIF1alpha-PPARgamma circuit controls a paradoxical adipocyte regulatory landscape

Takamasa Kudo, Michael L. Zhao, Kyle M. Kovary, Edward L. LaGory, Markus W. Covert, Mary N. Teruel

The paper identifies a dynamic HIF1alpha-PPARgamma circuit that both promotes and represses lipid accumulation during adipogenesis, revealing a mechanism for adipocyte dysfunction in obesity.

bioRxiv · May 17, 2022 · PreprintSystems Biology

Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity

Xingqi Chen, Ulrike M. Litzenburger, Yuning Wei, Alicia N. Schep, Edward L. LaGory, Hani Choudhry, Amato J. Giaccia, William James Greenleaf, Howard Y. Chang

The paper introduces Pi-ATAC, a method combining single-cell chromatin and proteomic profiling, revealing hypoxia's role in shaping the regulome in tumor cells.

Nature Communications · Oct 29, 2018Peer-reviewedGenomics