Spatial Analysis of T Cell Clonality in Autoimmune Kidney Disease Using TRV Probes
Cedric Ly, Darius P. Schaub, Robin Khatri, Zeba Sultana, Annika Boxnick, Song Zheng, Tobias Bruno Huber, Thorsten Wiech, Eva Tolosa, Ulf Panzer, Stefan Bonn, Christian F. Krebs, Immo Prinz
The paper develops an in situ hybridization method to analyze T cell clonality in kidney biopsies and finds spatial clustering of clonally related T cells near antigen-presenting cells.
bioRxiv · Aug 29, 2025 · PreprintImmunology