Eva Tolosa

Limited protection against early-life cytomegalovirus infection results from deficiency of cytotoxic CD8T cells

This study shows that deficiency of cytotoxic CD8 T cells in early life leads to limited protection against cytomegalovirus infection.

Selective persistence of HIV-1-infected T cell clones can occur through immune reprogramming driven by defective, transcriptionally active proviruses

This study shows that defective HIV-1 proviruses can reprogram CD4+ T cells by altering BACH2 and STAT5B gene expression, leading to immune evasion and persistence in ART-treated individuals.

Spatial Analysis of T Cell Clonality in Autoimmune Kidney Disease Using TRV Probes

The paper develops an in situ hybridization method to analyze T cell clonality in kidney biopsies and finds spatial clustering of clonally related T cells near antigen-presenting cells.

NSCLC patients with oligo-metastatic brain disease show an altered CD4 T-cells immune profile

The paper identifies altered CD4 T-cell immune profiles in NSCLC patients with oligo-metastatic brain disease compared to poly-metastatic disease and healthy controls.

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.