Stephen Wearne

The paper investigates how individual-specific microbial functions and host-microbe interactions influence skin recovery after barrier disruption in a human cohort.

This paper identifies two distinct MAP3K pathways activated by beetle toxins that trigger NLRP1 inflammasome activation in human keratinocytes.

The paper develops a skin metatranscriptomics workflow to analyze microbial gene activity across five skin sites in 27 healthy adults, revealing discrepancies between transcriptomic and genomic abundances and identifying key microbial pathways and antimicrobial genes.

This study investigates NLRP3 inflammasome activation in human keratinocytes, showing it is induced by IFN-gamma but not LPS, and that specific activators like Hla target NLRP3 while nigericin activates both NLRP1 and NLRP3.

The paper identifies prevalent skin microbiome configurations (dermotypes) across body sites and links them to host factors and disease risk.

The paper investigates how life stages affect the human skin microbiome and lipid mediators, finding microbial correlations with lipid profiles and cytokine production.