Clarifying the priming requirement and activator specificity for the NLRP3 inflammasome in human keratinocytes in vitro
Pritisha Rozario, Ying Shiang Lim, Shirley Suet Lee Ding, Muhammad Jasrie Firdaus, Stephen Wearne, Wong Han Siang Brandon, Rae Chua, Kim S. Robinson, Julie T. S. Chu, Liu Meng, Shan Sophie Carrie Cai, Sern Ting Eugene Tan, Soon Keong Wee, Mart Matthias Lamers, Navin Kumar Verma, , Franklin L. Zhong
This study investigates NLRP3 inflammasome activation in human keratinocytes, showing it is induced by IFN-gamma but not LPS, and that specific activators like Hla target NLRP3 while nigericin activates both NLRP1 and NLRP3.
bioRxiv · Aug 13, 2025 · PreprintImmunology