PhysiologyJournal of HepatologyPeer-reviewed
Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challenges
Panyun Wu, Yang Wang, Jonathan C. Cohen, Helen H. Hobbs
This study investigates tissue-specific regulation of PNPLA3 in mice, showing feeding increases hepatic PNPLA3 while cold exposure boosts it in brown adipose tissue through post-transcriptional mechanisms, linking it to lipid remodeling in response to metabolic stress.
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