Yang Wang

Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challenges

This study investigates tissue-specific regulation of PNPLA3 in mice, showing feeding increases hepatic PNPLA3 while cold exposure boosts it in brown adipose tissue through post-transcriptional mechanisms, linking it to lipid remodeling in response to metabolic stress.

PNPLA3(148M) Promotes Hepatic Steatosis by Interfering with Triglyceride Hydrolysis Through a Gain-of-Function Mechanism

ABHD5 binds PNPLA3 more strongly than ATGL regardless of the I148M variant; steatosis from PNPLA3(148M) needs ATGL and is reversed by ABHD5 overexpression.