Author

Javier Muñoz Briones

Purdue University West LafayetteORCID 0009-0003-1129-8105Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Douglas K. BrubakeriD· 4 shared Leopold N. GreeniD· 2 shared Smrutiti JenaiD· 2 shared Adam D BurgeneriD· 1 shared Alana LamontiD· 1 shared Alicia R. BerardiD· 1 shared Andrey ShuriD· 1 shared Brendan K. BalliD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersSystems Biology

Douglas K. BrubakerORCID

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4 papers

Recent·Most cited

Systems BiologyAnimal MicrobiomePeer-reviewedApr 11, 2026

Rumenomics: Evaluation of rumen metabolites from healthy sheep identifies differentially produced metabolites across sex, age, and weight

Javier Muñoz Briones, Brendan K. Ball, Smrutiti Jena…·Douglas K. Brubaker

DOI 10.1186/s42523-026-00558-5

metabolomicsstatistical model

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MicrobiologybioRxivPreprintAug 28, 2025

Identifying a Vaginal Microbiome-Derived Selective Antibiotic Metabolite via Microbiome Pharmacology Analysis

Smrutiti Jena, Damilola C. Lawore, Javier Muñoz Briones…·Douglas K. Brubaker

This study identifies a vaginal microbiome-derived antibiotic metabolite, Hydroxyisocaproate, using a systems biology approach to improve BV treatment.

1 citation

humanbulk RNA-seq

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Synthetic BiologyACS Synthetic BiologyPeer-reviewedNov 28, 2024

Diagnostic and Therapeutic Microbial Circuit with Application to Intestinal Inflammation

Liana N. Merk, Andrey Shur, Smrutiti Jena…·Leopold N. Green

This paper engineers a synthetic microbial circuit in E. coli to respond to two signals and secrete IL-22 for anti-inflammatory effects in a gut epithelial model.

3 citations

humanCRISPR screen

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Systems BiologybioRxivPreprintJul 8, 2022

Latent Interacting Variable-Effects Modeling of Gut Microbiome Multi-Omics in Inflammatory Bowel Disease

Javier Muñoz Briones, Douglas K. Brubaker

This paper introduces LIVE modeling to integrate microbiome multi-omics data in IBD, reducing feature correlations and identifying novel disease mechanisms.

2 citations

humanmetagenomics

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