Andrey Shur

This paper engineers a synthetic microbial circuit in E. coli to respond to two signals and secrete IL-22 for anti-inflammatory effects in a gut epithelial model.

BioCRNpyler compiles chemical reaction networks from modular biochemical parts, enabling rapid model development and exploration across diverse contexts.

This paper demonstrates a genetic circuit that records small molecule concentration changes in living cells using CRISPR-Cas9 and integrase-mediated DNA integration.

The paper describes a method to repress integrase activity at specific DNA sites using CRISPR-Cas9 in E. coli, achieving up to 8-fold repression of integration at identical attP sites.