Leopold N. Green

The paper develops a systems biology framework called the Pharmacobiome to analyze the anti-cancer potential of vaginal microbes and metabolites by comparing their effects on host gene expression to known drugs.

This study identifies a vaginal microbiome-derived antibiotic metabolite, Hydroxyisocaproate, using a systems biology approach to improve BV treatment.

This study compares metabolomic profiles of key vaginal microbes in planktonic and biofilm states, revealing species-specific metabolic shifts and growth mode-dependent differences.

This paper engineers a synthetic microbial circuit in E. coli to respond to two signals and secrete IL-22 for anti-inflammatory effects in a gut epithelial model.

The paper designs a biological controller using an ODE model to regulate immune response in septic wounds by addressing macrophage dysregulation.

The paper develops a dynamical population model and type-1 IFFL controller to simulate and improve wound healing dynamics.

The paper designs a synthetic bacterial community with population density control using feedback loops and molecular sequestration, showing absorbance methods overestimate population density when ccdB is used.