Author

Sebastian Treusch

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:GWAS / association mapping· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Leonid KruglyakiD· 4 shared Joshua S Bloom· 3 shared Frank W Albert· 2 shared Aayami Jain· 1 shared Adam SciambiiD· 1 shared Angelica Garcia· 1 shared Arthur H Shockley· 1 shared B. Joy Quejarro· 1 shared

Activity by Year

2013-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersGenetics

Leonid KruglyakORCID

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Author profile →

6 papers

Recent·Most cited

Functional Screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair

Juan A. Pérez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia, Trevor L. Gerstenberg, Kaisle A. Hill, Aayami Jain, Kristina Krassovsky, Cassandra D. Lalisan, , Kristen L. Seim

The paper identifies optimized protein-based enhancers of HDR in human HSPCs through functional screening, improving HDR efficiency without increasing off-target effects.

Nature Communications · Mar 23, 2024Peer-reviewedMolecular Biology

Rare variants contribute disproportionately to quantitative trait variation in yeast

Joshua S. Bloom, James Boocock, Sebastian Treusch, Meru J. Sadhu, Laura Day, Holly Oates-Barker, Leonid Kruglyak

This study shows rare DNA variants have a larger impact on quantitative traits in yeast compared to common variants, due to their greater effect sizes and recent evolutionary origins.

eLife · Oct 24, 2019Peer-reviewedGenetics

High-throughput single-cell DNA sequencing of AML tumors with droplet microfluidics

Maurizio Pellegrino, Adam Sciambi, Sebastian Treusch, Robert Durruthy-Durruthy, Kaustubh Gokhale, Jose P. Jacob, Tina X. Chen, Jennifer A. Geis, William M. Oldham, Jairo A. Matthews, Hagop M. Kantarjian, P. Andrew Futreal, Keyur Pravinchandra Patel, Keith W. Jones, Koichi Takahashi, Dennis J. Eastburn

This study develops a microfluidic method for single-cell DNA sequencing of AML tumors, revealing clonal evolution not detectable by bulk sequencing.

Genome Research · Sep 1, 2018Peer-reviewedGenomics

Genetic interactions contribute less than additive effects to quantitative trait variation in yeast

Joshua S Bloom, Iulia Kotenko, Meru J Sadhu, Sebastian Treusch, Frank W Albert, Leonid Kruglyak

The paper estimates the contribution of genetic interactions to quantitative trait variation in yeast and finds they account for 9% of phenotypic variance, less than additive effects.

bioRxiv · Oct 8, 2015Genetics

Genetic dissection of MAPK-mediated complex traits across S. cerevisiae

Sebastian Treusch, Frank W Albert, Joshua S Bloom, Iulia E Kotenko, Leonid Kruglyak

This study identifies genetic variants influencing MAPK signaling phenotypes in S. cerevisiae using QTL mapping across diverse strains.

PLoS Genetics · Jan 8, 2015Peer-reviewedGenetics

Genetics of single-cell protein abundance variation in large yeast populations

Frank Albert, Sebastian Treusch, Arthur H Shockley, Joshua S Bloom, Leonid Kruglyak

The paper develops a method to identify genetic loci influencing protein abundance in yeast and finds more loci per gene than previous studies, with many loci affecting multiple proteins.

bioRxiv · Nov 7, 2013Genomics