A temporary challenge by tumor cells can lead to a permanent partial-impairment of memory CD8 T cell function
Daphné Laubreton, Margaux Prieux, Sophia Djebali, M. Dubois, Simon de Bernard, Olivier Gandrillon, Christophe Arpin, Jacqueline Marvel
This study compares memory CD8 T cells generated from tumor rejection and acute viral infection, finding that tumor-induced cells show persistent functional defects similar to exhaustion.
bioRxiv · Feb 17, 2025 · PreprintImmunology