ImmunologybioRxivPreprint
Binding of inhibitory checkpoints to CD18 in cis hinders anti-cancer immune responses
Zheng-Hai Tang, Ming‐Chao Zhong, Jin Qian…·André Veillette
The paper shows inhibitory checkpoints like SIRP and PD-1 hinder anti-cancer immune responses by cis-interacting with CD18, in addition to their trans interactions with tumor cell ligands.
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