Binding of inhibitory checkpoints to CD18 in cis hinders anti-cancer immune responses
Zheng-Hai Tang, Ming‐Chao Zhong, Jin Qian, Lok San Wong, Jiaxin Li, Dominique Davidson, André Veillette
The paper shows inhibitory checkpoints like SIRP and PD-1 hinder anti-cancer immune responses by cis-interacting with CD18, in addition to their trans interactions with tumor cell ligands.
bioRxiv · Sep 10, 2025 · PreprintImmunology