Noa Popko

The paper evaluates how different model architectures, LD filtering thresholds, and variant prioritization methods affect gene-level eQTL score prediction quality using over 3 million models.

This study identifies distinct causes for three hematopoietic aging phenotypes using mouse models and single-cell analysis, showing HSC accumulation is NFκB-independent, functional impairment is HSC-autonomous NFκB-driven, and myeloid bias is driven by the NFκB-altered bone marrow environment.