Author

Dennis J. Chia

University of California, Los AngelesORCID 0000-0002-5060-9442Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alexander HoffmanniD· 1 shared Apeksha SinghiD· 1 shared Ashlyn A. BuzzelliiD· 1 shared Caitlyn L. H. Pham· 1 shared Christian G. BustillosiD· 1 shared Christina Reh· 1 shared David Mastro· 1 shared David Sailer· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Alexander HoffmannORCID

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2 papers

Recent·Most cited

UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes

Ho-Chung Chen, Madison F. Bang, Hsing‐Hui Wang, Karl B. Shpargel, Lisa A. Kohn, David Sailer, S.C. Zhang, Ethan C. McCarthy, Maryamsadat Seyedsadr, Satchel Stevens, Caitlyn L. H. Pham, Zikang Zhou, Xihui Yin, Nicole M. Wilkinson, Esther Peluso, , Maureen A. Su

This study identifies UTX's role in regulating progenitor CD8+ T cell fate in T1D by interacting with TCF1 and STAT3, showing its importance in autoimmune diabetes progression.

Journal of Clinical Investigation · Dec 16, 2025Peer-reviewedImmunology

Distinct causes of three phenotypic hallmarks of hematopoietic aging

Dennis J. Chia, Apeksha Singh, Yusheng Lin, Noa Popko, David Mastro, Yi Liu, Tiffany M. Tran, Jennifer K. King, Dinesh S. Rao, Alexander Hoffmann

This study identifies distinct causes for three hematopoietic aging phenotypes using mouse models and single-cell analysis, showing HSC accumulation is NFκB-independent, functional impairment is HSC-autonomous NFκB-driven, and myeloid bias is driven by the NFκB-altered bone marrow environment.

Cell Reports · Aug 26, 2025Peer-reviewedImmunology