NeurosciencebioRxivPreprint
Enhanced proconvulsant sensitivity, not spontaneous rapid swimming activity, is a robust correlate of scn1lab loss-of-function in stable mutant and F0 crispant hypopigmented zebrafish expressing GCaMP6s
Christopher Michael McGraw, Cristina M. Baker, Annapurna Poduri
The paper evaluates scn1lab loss-of-function in zebrafish using calcium and movement data, finding enhanced proconvulsant sensitivity as a reliable indicator despite suppressive effects from genetic background and pigmentation.